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Page 1
Cross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle Assembly.
Asteriti IA, De Mattia F, Guarguaglini G. Asteriti IA, et al. Front Oncol. 2015 Dec 23;5:283. doi: 10.3389/fonc.2015.00283. eCollection 2015. Front Oncol. 2015. PMID: 26779436 Free PMC article. Review.
The Aurora kinase A (AURKA) is involved in different aspects of mitotic control, from mitotic entry to cytokinesis. ...Bora has been described as an essential cofactor of AURKA for phosphorylation-mediated activation of the mitotic kinase …
The Aurora kinase A (AURKA) is involved in different aspects of mitotic control, from mitotic entry to cytokines …
Higher AURKA and PLK1 expression are associated with inferior overall survival in patients with myelofibrosis.
Galusic D, Lucijanic M, Livun A, Radman M, Blaslov V, Vicelic Cutura L, Petric M, Miljak A, Lucijanic J, Drmic Hofman I, Kusec R. Galusic D, et al. Blood Cells Mol Dis. 2020 Mar;81:102396. doi: 10.1016/j.bcmd.2019.102396. Epub 2019 Dec 5. Blood Cells Mol Dis. 2020. PMID: 31837568
Aurora-kinase-A (AURKA), BORA and Polo-like-kinase-1 (PLK1) are regulating cell-cycle control and promotion of mitosis entry. ...We aimed to investigate AURKA, BORA and PLK1 mRNA expression in unfractionated bone-marrow aspirates o …
Aurora-kinase-A (AURKA), BORA and Polo-like-kinase-1 (PLK1) are regulating cell-cycle control and promoti …
Bora and Aurora-A continue to activate Plk1 in mitosis.
Bruinsma W, Macurek L, Freire R, Lindqvist A, Medema RH. Bruinsma W, et al. J Cell Sci. 2014 Feb 15;127(Pt 4):801-11. doi: 10.1242/jcs.137216. Epub 2013 Dec 11. J Cell Sci. 2014. PMID: 24338364
Plk1 is first phosphorylated on T210 in G2 phase by the kinase Aurora-A, in concert with its cofactor Bora. However, Bora was shown to be degraded prior to entry into mitosis, and it is currently unclear how Plk1 activity is sustained in mitosis. Here we show that t …
Plk1 is first phosphorylated on T210 in G2 phase by the kinase Aurora-A, in concert with its cofactor Bora. However, Bora was …
Bora regulates meiotic spindle assembly and cell cycle during mouse oocyte meiosis.
Zhai R, Yuan YF, Zhao Y, Liu XM, Zhen YH, Yang FF, Wang L, Huang CZ, Cao J, Huo LJ. Zhai R, et al. Mol Reprod Dev. 2013 Jun;80(6):474-87. doi: 10.1002/mrd.22185. Epub 2013 May 28. Mol Reprod Dev. 2013. PMID: 23610072
In this study, we examined the expression, localization, and function of Bora during mouse oocyte meiosis. The expression level of Bora was increased during oocyte meiotic maturation, with an elevated level at metaphase. ...In metaphase-II-arrested oocytes, Bora …
In this study, we examined the expression, localization, and function of Bora during mouse oocyte meiosis. The expression level of …
ZNF300 promotes chemoresistance and aggressive behaviour in non-small-cell lung cancer.
Yu S, Ao Z, Wu Y, Song L, Zhang P, Li X, Liu M, Qian P, Zhang R, Li X, Chen Y, Wang X, Wang X, Ruan X, Qian G, Ji F. Yu S, et al. Cell Prolif. 2020 Nov;53(11):e12924. doi: 10.1111/cpr.12924. Epub 2020 Oct 19. Cell Prolif. 2020. PMID: 33078469 Free PMC article.
ZNF300 inhibited MAPK/ERK pathways and activated CDK1 through inhibiting WEE1 and MYT1 and modulating MYC/AURKA/BORA/PLK1 axis. ICA and ATRA improved the anti-tumour effect of cisplatin on chemoresistant cells by inducing differentiation. CONCLUSIONS: ZNF300 promote …
ZNF300 inhibited MAPK/ERK pathways and activated CDK1 through inhibiting WEE1 and MYT1 and modulating MYC/AURKA/BORA/PLK1 axis …
Aurora-PLK1 cascades as key signaling modules in the regulation of mitosis.
Joukov V, De Nicolo A. Joukov V, et al. Sci Signal. 2018 Aug 14;11(543):eaar4195. doi: 10.1126/scisignal.aar4195. Sci Signal. 2018. PMID: 30108183 Review.
We review collected evidence that in vertebrates, the Aurora kinases serve as catalytic subunits of distinct complexes formed with the four scaffold proteins Bora, CEP192, INCENP, and TPX2, which we deem "core" Aurora cofactors. These complexes and the Aurora-PLK1 cascades …
We review collected evidence that in vertebrates, the Aurora kinases serve as catalytic subunits of distinct complexes formed with the four …
Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry.
Tavernier N, Thomas Y, Vigneron S, Maisonneuve P, Orlicky S, Mader P, Regmi SG, Van Hove L, Levinson NM, Gasmi-Seabrook G, Joly N, Poteau M, Velez-Aguilera G, Gavet O, Castro A, Dasso M, Lorca T, Sicheri F, Pintard L. Tavernier N, et al. Nat Commun. 2021 Mar 26;12(1):1899. doi: 10.1038/s41467-021-21922-w. Nat Commun. 2021. PMID: 33771996 Free PMC article.
Plk1 is activated by phosphorylation on a conserved residue Thr210 in its activation segment by the Aurora A kinase (AURKA), a reaction that critically requires the co-factor Bora phosphorylated by a CyclinA/B-Cdk1 kinase. Here we show that phospho-Bora is a …
Plk1 is activated by phosphorylation on a conserved residue Thr210 in its activation segment by the Aurora A kinase (AURKA), a reacti …
SUMO proteases SENP3 and SENP5 spatiotemporally regulate the kinase activity of Aurora A.
Yu B, Lin Q, Huang C, Zhang B, Wang Y, Jiang Q, Zhang C, Yi J. Yu B, et al. J Cell Sci. 2021 Jul 1;134(13):jcs249771. doi: 10.1242/jcs.249771. Epub 2021 Jul 8. J Cell Sci. 2021. PMID: 34313310
Precise chromosome segregation is mediated by a well-assembled mitotic spindle, which requires balance of the kinase activity of Aurora A (AurA, also known as AURKA). However, how this kinase activity is regulated remains largely unclear. Here, using in vivo and in vitro a …
Precise chromosome segregation is mediated by a well-assembled mitotic spindle, which requires balance of the kinase activity of Aurora A (A …
Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos.
Tavernier N, Noatynska A, Panbianco C, Martino L, Van Hove L, Schwager F, Léger T, Gotta M, Pintard L. Tavernier N, et al. J Cell Biol. 2015 Mar 16;208(6):661-9. doi: 10.1083/jcb.201408064. Epub 2015 Mar 9. J Cell Biol. 2015. PMID: 25753036 Free PMC article.
Here, we show that the mitotic kinase CDK-1 phosphorylates Suppressor of Par-Two 1 (SPAT-1)/Bora to regulate its interaction with PLK-1 and to trigger mitotic entry in early Caenorhabditis elegans embryos. ...We further show that phospho-SPAT-1 activates PLK-1 by triggerin …
Here, we show that the mitotic kinase CDK-1 phosphorylates Suppressor of Par-Two 1 (SPAT-1)/Bora to regulate its interaction with PLK …
Deciphering the Interplay among Multisite Phosphorylation, Interaction Dynamics, and Conformational Transitions in a Tripartite Protein System.
Lössl P, Brunner AM, Liu F, Leney AC, Yamashita M, Scheltema RA, Heck AJ. Lössl P, et al. ACS Cent Sci. 2016 Jul 27;2(7):445-55. doi: 10.1021/acscentsci.6b00053. Epub 2016 Jun 10. ACS Cent Sci. 2016. PMID: 27504491 Free PMC article.
Here, we integrate complementary mass spectrometry (MS)-based approaches to characterize a multisite phosphorylation-regulated protein system comprising Polo-like kinase 1 (Plk1) and its coactivators Aurora kinase A (Aur-A) and Bora, the interplay of w …
Here, we integrate complementary mass spectrometry (MS)-based approaches to characterize a multisite phosphorylation-regulated protein syste …
20 results